Unification of Treatments and Interventions for Tinnitus Patients - UNITI

The Statistical Analysis Plan for the UNITI Project Randomized Clinical Trial is now available! The UNITI trial will be one of the world’s largest tinnitus trials and the first to compare established standard treatments performed alone or in combination. The results of the UNITI trial will provide much-needed evidence to clinicians and are likely to influence international clinical guidelines. The planned statistical analysis is detailed here to provide transparency. For more information about the statistical analysis plan visit here: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07303-2.

RCT results are coming soon!

Members of the UNITI consortium had the opportunity to meet at Mario Negri Institute (Milan) on the 27th and 28th of June 2023. The main topic of this meeting was to discuss the results of the socio-economic questionnaire, i.e. what are the costs associated with tinnitus. Strategic decisions were made and a manuscript is being prepared. From an exploitation and sustainability point of view, it was considered important to develop a new questionnaire based on the lessons learnt during the analysis of our results (which questions are important and which ones need to be modified or eliminated). General guidelines will be integrated into the final paper, and the idea is to propose the questionnaire as an appendix to the manuscript. 

We are pleased to announce that that we had the opportunity to host a UNITI session at the Tinnitus Research Inititative Conference 2023, held at Trinity College in Dublin from 6 to 9 June 2023. During the UNITI session we shared insights about the progress of the project. More specifically we presented the UNITI DSS, the results of the socioeconomic analysis and the preliminary results of the UNITI RCTs.

It was an exciting experience to discuss our work with fellow researchers and professionals in the field.

A Special Issue on "The Journey of Hearing and Hearing-Related Disorders over Time" is now available here: https://www.mdpi.com/journal/jcm/special_issues/B57567CJJO. 

Hearing is a critical sense, which is a prerequisite for interpersonal communication, perception of the environment, and social interaction. However, hearing competence is not a stable capability but changes over time due to various reasons such as aging, acquired diseases, infections, environmental influences, and more.

This special issue welcomes original research articles and systematic reviews on the development of hearing or hearing-related disorders (e. g. tinnitus or hyperacusis) over time, the impact of an interaction between hearing loss and hearing-related disorders on the progress, the influence of potential treatments and methods to evaluate progression of hearing loss over time.

The 2nd UNITI Hackathon tool place in Granada, Spain between 7-9 February 2023 and it was a great success. Partners of UNITI consortium split into two main groups. The Writing group that focused on writing two manuscripts, one for the main UNITI results from the RCTs and one for the socio-economic study. The Data analysis group focused on analysing all UNITI data available. A significan amount of data is available and in the next months the consortium will work towards analysing this data. Several publications are expected towards this direction. Furthermore, the consortium is also investigating ways of exploiting the data and releasing it as open in order for the tinnitus research community to continue working on this data.