The project started in January 2020.

Listed in the below table, you will find all scientific publications by the UNITI consortium published during the entire project duration.

2020 - 2023

Journal publications

pdf Engelke M, Simões J, Vogel C, Schoisswohl S, Schecklmann M, Wölflick S, et al. (2023) Pilot study of a smartphone-based tinnitus therapy using structured counseling and sound therapy: A multiple-baseline design with ecological momentary assessment. PLOS Digit Health 2(1): e0000183. pdig.0000183
pdf Haro-Hernandez, P., Perez-Carpena, P., Unnikrishnan, V., Spiliopoulou, M., & Lopez-Escamez, J.A. (2022). Standardized Clinical Profiling in Spanish Patients with Chronic Tinnitus. Journal of Clinical Medicine 11(4), 978.
pdf Roman-Naranjo, P., Parra-Perez, A.M. Escalera-Balsera, A., Soto-Varela, A., Gallego-Martinez. A., Aran, I., ... & Lopez-Escamez, J.A. (2022). Defective α-tectorin may involve tectorial membrane in familial Menière disease. Clinical and Translational Medicine 12(6)
pdf Trpchevska N, Freidin MB, Broer L, Oosterloo BC, Yao S, Zhou Y, Vona B, Bishop C, Bizaki-Vallaskangas A, Canlon B, Castellana F, Chasman DI, Cherny S, Christensen K, Concas MP, Correa A, Elkon R; Estonian Biobank Research Team, Mengel-From J, Gao Y, Giersch ABS, Girotto G, Gudjonsson A, Gudnason V, Heard-Costa NL, Hertzano R, Hjelmborg JVB, Hjerling-Leffler J, Hoffman HJ, Kaprio J, Kettunen J, Krebs K, Kähler AK, Lallemend F, Launer LJ, Lee IM, Leonard H, Li CM, Lowenheim H, Magnusson PKE, van Meurs J, Milani L, Morton CC, Mäkitie A, Nalls MA, Nardone GG, Nygaard M, Palviainen T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal CL, Schweinfurth JM, Seshadri S, Shiroma E,Shulman E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CR, Williams FMK, Nagtegaal AP. Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss. Am J Hum Genet. 2022 Jun 2;109(6):1077-1091. doi:10.1016/j.ajhg.2022.04.010. Epub 2022 May 16. PMID: 35580588
pdf Shahania, S., Unnikrishnan, V., Pryss, R., Kraft, R., Schobel, J., Hannemann, R., ... & Spiliopoulou, M. (2022). Predicting Ecological Momentary Assessments in an App for Tinnitus by Learning From Each User's Stream With a Contextual Multi-Armed Bandit. Frontiers in neuroscience, 16.
pdf Jarach, C. M., Lugo, A., Stival, C., Bosetti, C., Amerio, A., Cavalieri d'Oro, L., Iacoviello L, Odone A, Stuckler D, Zucchi A, van den Brandt P, Garavello W, Cederroth CR, Schlee W, Gallus S and the LOST in Lombardia Study Investigators (2022). The impact of COVID-19 confinement on tinnitus and hearing loss in older adults: data from the LOST in Lombardia study. Frontiers in Neurology, 366. 
pdf Edvall NK, Mehraei G., Claeson M., Lazar A., Bulla J., Leineweber C., Uhlén I., Canlon B., Cederroth CR. (2022). Alterations in auditory brainstem response distinguish occasional and constant tinnitus. J Clin Invest. 2022 Jan 25:e155094. doi: 10.1172/JCI155094. Epub ahead of print. PMID: 35077399.
pdf Prakash S, Unnikrishnan V, Pryss R, Kraft R, Schobel J, Hannemann R, Langguth B, Schlee W, Spiliopoulou M. (2021) Interactive System for Similarity-Based Inspection and Assessment of the Well-Being of mHealth Users. Entropy. 2021; 23(12):1695.
only abstract available Puga, C., Niemann, U., Unnikrishnan, V., Schleicher, M., Schlee, W., & Spiliopoulou, M. (2021, October). Discovery of Patient Phenotypes through Multi-layer Network Analysis on the Example of Tinnitus. In 2021 IEEE 8th International Conference on Data Science and Advanced Analytics (DSAA) (pp. 1-10). IEEE.
only abstract available Genitsaridi E, Kypraios T, Edvall NK, Trpchevska N, Canlon B, Hoare DJ, Cederroth CR, Hall DA (2021). The spatial percept of tinnitus is associated with hearing asymmetry: Subgroup comparisons. Prog Brain Res. 2021;263:59-80. doi: 10.1016/bs.pbr.2021.04.00610.1016/bs.pbr.2021.04.006. Epub 2021 May 20. PMID: 4243891.
only abstract available Biswas R, Lugo A, Genitsaridi E, Trpchevska N, Akeroyd MA, Cederroth CR, Liu X, Schlee W, Garavello W, Gallus S, Hall DA (2021). Modifiable lifestyle-related risk factors for tinnitus in the general population: An overview of smoking, alcohol, body mass index and caffeine intake. Prog Brain Res. 2021;263:1-24. doi:10.1016/bs.pbr.2021.04.005. Epub 2021 May 20. PMID: 34243884

Schoisswohl, S., Langguth, B., Schecklmann, M., Boecking, B., Cederroth, C., Chalanouli, D., ... & Schlee, W. (2021). Unification of treatments and interventions for tinnitus patients (UNITI): a study protocol for a multi-center randomized clinical trial. Trials 22, 875 (2021).


Amanat, S., Gallego-Martinez, A., Sollini, J., Perez-Carpena, P., Espinosa-Sanchez, J. M., Aran, I., ... & Lopez-Escamez, J. A. (2021). Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine, 66, 103309.


Trochidis I, Lugo A, Borroni E, Cederroth CR, Cima R, Kikidis D, Langguth B, Schlee W, Gallus S. Systematic Review on Healthcare and Societal Costs of Tinnitus. International Journal of Environmental Research and Public Health. 2021; 18(13):6881.

only abstract available

Schlee, W., Langguth, B., Pryss, R., Allgaier, J., Mulansky, L., Vogel, C., Spiliopoulou, M., Schleicher, M., Unnikrishnan, V., Puga, C., Manta, O., Sarafidis, M., Kouris, I., Vellidou, E., Koutsouris, D., Koloutsou, K., Spanoudakis, G., Cederroth, C., & Kikidis, D. (2021). Using Big Data to Develop a Clinical Decision Support System for Tinnitus Treatment. Current topics in behavioral neurosciences, 10.1007/7854_2021_229. Advance online publication.


Kikidis, D., Vassou, E., Schlee, W., Iliadou, E., Markatos, N., Triantafyllou, A., & Langguth, B. (2021). Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers Journal of clinical medicine, 10(8), 1737.

only abstract available

Schlee W, Schoisswohl S, Staudinger S, Schiller A, Lehner A, Langguth B, Schecklmann M, Simoes J, Neff P, Marcrum SC, Spiliopoulou M, Niemann U, Schleicher M, Unnikrishnan V, Puga C, Mulansky L, Pryss R, Vogel C, Allgaier J, Giannopoulou E, Birki K, Liakou K, Cima R, Vlaeyen JWS, Verhaert N, Ranson S, Mazurek B, Brueggemann P, Boecking B, Amarjargal N, Specht S, Stege A, Hummel M, Rose M, Oppel K, Dettling-Papargyris J, Lopez-Escamez JA, Amanat S, Gallego-Martinez A, Escalera-Balsera A, Espinosa-Sanchez JM, Garcia-Valdecasas J, Mata-Ferron M, Martin-Lagos J, Martinez-Martinez M, Martinez-Martinez MJ, Müller-Locatelli N, Perez-Carpena P, Alcazar-Beltran J, Hidalgo-Lopez L, Vellidou E, Sarafidis M, Katrakazas P, Kostaridou V, Koutsouris D, Manta R, Paraskevopoulos E, Haritou M, Elgoyhen AB, Goedhart H, Koller M, Shekhawat GS, Crump H, Hannemann R, Holfelder M, Oberholzer T, Vontas A, Trochidis I, Moumtzi V, Cederroth CR, Koloutsou K, Spanoudakis G, Basdekis I, Gallus S, Lugo A, Stival C, Borroni E, Markatos N, Bibas A, Kikidis D. (2021). Towards a unification of treatments and interventions for tinnitus patients: The EU research and innovation action UNITI. Progress in brain research, 260, 441–451.

pdf Schleicher, M., Unnikrishnan, V., Neff, P., Simoes, J., Probst, T., Pryss, R., Schlee, W. & Spiliopoulou, M. (2020). Understanding adherence to the recording of ecological momentary assessments in the example of tinnitus monitoring. Scientific Reports, 10, 22459 (2020).

Unnikrishnan, V., Schleicher, M., Shah, Y., Jamaludeen, N., Pryss, R., Schobel, J., Kraft, R., Schlee, W., & Spiliopoulou, M. (2020). The Effect of Non-Personalised Tips on the Continued Use of Self-Monitoring mHealth Applications. Brain sciences, 10(12), 924.


Trpchevska, N., Bulla, J., Prada Hellberg, M., Edvall, N. K., Lazar, A., Mehraei, G., Uhlen, I., Schlee, W., Canlon, B., Gallus, S., Lopez-Escamez, J. A., & Cederroth, C. R. (2020). Sex-Dependent Aggregation of Tinnitus in Swedish Families. Journal of clinical medicine, 9(12), 3812.


Schlee, W., Hølleland, S., Bulla, J., Simoes, J., Neff, P., Schoisswohl, S., Woelflick, S., Schecklmann, M., Schiller, A., Staudinger, S., Probst, T., & Langguth, B. (2020). The Effect of Environmental Stressors on Tinnitus: A Prospective Longitudinal Study on the Impact of the COVID-19 Pandemic. Journal of clinical medicine, 9(9), 2756.


Cederroth, C. R., Lugo, A., Edvall, N. K., Lazar, A., Lopez-Escamez, J. A., Bulla, J., Uhlen, I., Hoare, D. J., Baguley, D. M., Canlon, B., & Gallus, S. (2020). Association between Hyperacusis and Tinnitus. Journal of clinical medicine, 9(8), 2412.

pdf Niemann, U., Brueggemann, P., Boecking, B., Mebus, W., Rose, M., Spiliopoulou, M., & Mazurek, B. (2020). Phenotyping chronic tinnitus patients using self-report questionnaire data: Cluster analysis and visual comparison. Scientific reports, 10(1), 1-10.
ISO 690.
pdf Niemann, U., Boecking, B., Brueggemann, P., Mazurek, B., & Spiliopoulou, M. (2020). Gender-Specific Differences in Patients With Chronic Tinnitus-Baseline Characteristics and Treatment Effects. Frontiers in neuroscience, 14, 487.
pdf Niemann U, Brueggemann P, Boecking B, Mazurek B, Spiliopoulou M. (2020) Development and internal validation of a depression severity prediction model for tinnitus patients based on questionnaire responses and socio-demographics. Scientific reports. 2020 Mar 13;10(1):1-9.

Niemann U, Boecking B, Brueggemann P, Mebus W, Mazurek B, Spiliopoulou M. (2020) Tinnitus related distress after multimodal treatment can be characterized using a key subset of baseline variables. PLoS One. 2020 Jan 30;15(1):e0228037. PMID: 31999776; PMCID: PMC6991951.


Conference technical papers 


Shahania, S., Unnikrishnan, V., Pryss, R., Kraft, R., Schobel, J., Hannemann, R., Schlee, W., & Spiliopoulou, M. (2021, June). User-centric vs whole-stream learning for EMA prediction. In 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 307-312). IEEE.

pdf Unnikrishnan, V., Shah, Y., Schleicher, M., Fernández-Viadero, C., Strandzheva, M., Velikova, D., Schlee, W., & Spiliopoulou, M. (2021, June). Love thy Neighbours: A Framework for Error-Driven Discovery of Useful Neighbourhoods for One-Step Forecasts on EMA data. In 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 295-300). IEEE.
pdf Jamaludeen, N., Unnikrishnan, V., Pryss, R., Schobel, J., Schlee, W., & Spiliopoulou, M. (2021, June). Circadian Conditional Granger Causalities on Ecological Momentary Assessment Data from an mHealth App. In 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 354-359). IEEE.
pdf  Sarafidis, M., Manta, O., Kouris, I.N., Schlee, W., Kikidis, D., Vellidou, E., & Koutsouris, D.D. (2021). Why a Clinical Decision Support System is needed for Tinnitus?. 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).
pdf Allgaier, J., Neff, P., Schlee, W., Schoisswohl, S., & Pryss, R. (2021). Deep Learning End-to-End Approach for the Prediction of Tinnitus based on EEG Data. 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).
pdf Vogel, C., Schobel, J., Schlee, W., Engelke, M., & Pryss, R. (2021). UNITI Mobile - EMI-Apps for a Large-Scale European Study on Tinnitus. ArXiv, abs/2107.14029. 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).

UNITI Randomized Clinical Trial

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