The project started in January 2020.
Listed in the below table, you will find all scientific publications by the UNITI consortium published during the entire project duration.
2020 - 2023
Journal publications
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Puga, C., Niemann, U., Schlee, W., & Spiliopoulou, M. (2023). A cost-based multi-layer network approach for the discovery of patient phenotypes. International Journal of Data Science and Analytics, 1-21. https://doi.org/10.48550/arXiv.2209.09032 |
| paper available for download | Simoes J.P., Schoisswohl, S., Schlee, W., Basso, L., Bernal-Robledano, A., Boecking, B., Cima, R., Denys, S., Engelke, M., Escalera-Balsera, A., Gallego-Martinez, A., Gallus, S., Kikidis, D., López-Escámez, J.A., Marcrum, S.C., Markatos, N., Martin-Lagos, J., Martinez-Martinez, M., Mazurek, B., Vassou, E., Jarach, C.M., Mueller-Locatelli, N., Neff, P., Niemann, U., Kader Omar, H., Puga, C., Schleicher, M., Unnikrishnan, V., Perez-Carpena, P., Pryss, R., Robles-Bolivar, P., Rose, M., Schecklmann, M., Schiele, T., Schobel, J., Spiliopoulou, M., Stark, S., Vogel, C., Wunder, N., Zachou, Z. & Langguth, B. (2023). The statistical analysis plan for the unification of treatments and interventions for tinnitus patients randomized clinical trial (UNITI-RCT). Trials 24, 472 (2023). https://doi.org/10.1186/s13063-023-07303-2 |
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Mazurek, B., Schulze, H., Schlee, W., & Dobel, C. (2023). Tinnitus at the Junction of Traditional Medicine and Modern Technology. Nutrients, 15(8), 1898. https://doi.org/10.3390/nu15081898
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Schoisswohl, S., Langguth, B., Weber, F. C., Abdelnaim, M. A., Hebel, T., & Schecklmann, M. (2023). Activate & fire: a feasibility study in combining acoustic stimulation and continuous theta burst stimulation in chronic tinnitus. BMC neurology, 23(1), 14. https://doi.org/10.1186/s12883-022-03036-y |
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Engelke M, Simões J, Vogel C., Schoisswohl S, Schecklmann M, Wölflick S, Pryss R, Probst Th, Langguth B, Schlee W (2023). Pilot study of a smartphone-based tinnitus therapy using structured counseling and sound therapy: A multiple-baseline design with ecological momentary assessment. PLOS Digit Health 2(1): e0000183. https://doi.org/10.1371/journal.pdig.0000183 |
| Οnly abstract available | Schoisswohl, S., Langguth, B., Weber, F. C., Abdelnaim, M. A., Hebel, T., Mack, W., & Schecklmann, M. (2022). One way or another: treatment effects of 1 Hz rTMS using different current directions in a small sample of tinnitus patients. Neuroscience Letters, 137026. https://doi.org/10.1016/j.neulet.2022.137026 |
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Schlee W, Neff P, Simoes J, Langguth B, Schoisswohl S, Steinberger H, Norman M, Spiliopoulou M, Schobel J, Hannemann R, Pryss R. Smartphone-Guided Educational Counseling and Self-Help for Chronic Tinnitus. Journal of Clinical Medicine. 2022; 11(7):1825.https://doi.org/10.3390/jcm11071825 |
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Allgaier, J., Schlee, W., Probst, T., & Pryss, R. (2022). Prediction of Tinnitus Perception Based on Daily Life MHealth Data Using Country Origin and Season. Journal of Clinical Medicine, 11(15), 4270. https://doi.org/10.3390%2Fjcm11154270 |
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Weber, F. C., Schlee, W., Langguth, B., Schecklmann, M., Schoisswohl, S., Wetter, T. C., & Simões, J. (2022). Low Sleep Satisfaction Is Related to High Disease Burden in Tinnitus. International Journal of Environmental Research and Public Health, 19(17), 11005. https://doi.org/10.3390/ijerph191711005 |
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Marcrum, S. C., Engelke, M., Goedhart, H., Langguth, B., Schlee, W., Vesala, M., & Simoes, J. P. (2022). The Influence of Diet on Tinnitus Severity: Results of a Large-Scale. Online Survey. Nutrients, 14(24), 5356.https://doi.org/10.3390/nu14245356 |
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Simoes, J. P., Daoud, E., Shabbir, M., Amanat, S., Assouly, K., Biswas, R., ... & Genitsaridi, E. (2021). Multidisciplinary tinnitus research: challenges and future directions from the perspective of early stage researchers. Frontiers in Aging Neuroscience, 13, 179. https://doi.org/10.3389/fnagi.2021.647285 |
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Jarach, C. M., Lugo, A., Scala, M., van den Brandt, P. A., Cederroth, C. R., Odone, A., ... & Gallus, S. (2022). Global prevalence and incidence of tinnitus: A systematic review and meta-analysis. JAMA neurology.https://doi.org/10.1001/jamaneurol.2022.2189 |
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Schoisswohl, S., Langguth, B., Hebel, T., Vielsmeier, V., Abdelnaim, M. A., & Schecklmann, M. (2022). Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Subjective Tinnitus. Brain Sciences, 12(2), 203. https://doi.org/10.3390/brainsci12020203 |
| Only abstract available | Schlee, W., Kraft, R., Schobel, J., Langguth, B., Probst, T., Lourenco, M. P., ... & Pryss, R. (2023). Momentary assessment of tinnitus—How smart mobile applications advance our understanding of tinnitus. In Digital Phenotyping and Mobile Sensing (pp. 285-303). Springer, Cham. https://psycnet.apa.org/doi/10.1007/978-3-030-31620-4_13 |
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Manta, O., Sarafidis, M., Vasileiou, N., Schlee, W., Consoulas, C., Kikidis, D., ... & Koutsouris, D. D. (2022). Development and Evaluation of Automated Tools for Auditory-Brainstem and Middle-Auditory Evoked Potentials Waves Detection and Annotation. Brain Sciences, 12(12), 1675. https://doi.org/10.3390/brainsci12121675 |
| Only abstract available | Genitsaridi E, Kypraios T, Edvall NK, Trpchevska N, Canlon B, Hoare DJ, Cederroth CR, Hall DA (2021). The spatial percept of tinnitus is associated with hearing asymmetry: Subgroup comparisons. Prog Brain Res. 2021;263:59-80.https://doi.org/10.1016/bs.pbr.2021.04.006 |
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Lopez-Escamez, J. A., & Perez-Carpena, P. (2022). Technological Advances in the Diagnosis and Management of Tinnitus. Journal of Clinical Medicine, 11(15), 4597. https://doi.org/10.3390%2Fjcm11154597 |
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Biswas, R., Genitsaridi, E., Trpchevska, N., Lugo, A., Schlee, W., Cederroth, C. R., ... & Hall, D. A. (2022). Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis. Journal of the Association for Research in Otolaryngology, 1-14. https://doi.org/10.1007/s10162-022-00874-y |
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Haro-Hernandez, P., Perez-Carpena, P., Unnikrishnan, V., Spiliopoulou, M., & Lopez-Escamez, J.A. (2022). Standardized Clinical Profiling in Spanish Patients with Chronic Tinnitus. Journal of Clinical Medicine 11(4), 978. |
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Roman-Naranjo, P., Parra-Perez, A.M. Escalera-Balsera, A., Soto-Varela, A., Gallego-Martinez. A., Aran, I., ... & Lopez-Escamez, J.A. (2022). Defective α-tectorin may involve tectorial membrane in familial Menière disease. Clinical and Translational Medicine 12(6) |
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Trpchevska N, Freidin MB, Broer L, Oosterloo BC, Yao S, Zhou Y, Vona B, Bishop C, Bizaki-Vallaskangas A, Canlon B, Castellana F, Chasman DI, Cherny S, Christensen K, Concas MP, Correa A, Elkon R; Estonian Biobank Research Team, Mengel-From J, Gao Y, Giersch ABS, Girotto G, Gudjonsson A, Gudnason V, Heard-Costa NL, Hertzano R, Hjelmborg JVB, Hjerling-Leffler J, Hoffman HJ, Kaprio J, Kettunen J, Krebs K, Kähler AK, Lallemend F, Launer LJ, Lee IM, Leonard H, Li CM, Lowenheim H, Magnusson PKE, van Meurs J, Milani L, Morton CC, Mäkitie A, Nalls MA, Nardone GG, Nygaard M, Palviainen T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal CL, Schweinfurth JM, Seshadri S, Shiroma E,Shulman E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CR, Williams FMK, Nagtegaal AP. Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss. Am J Hum Genet. 2022 Jun 2;109(6):1077-1091. doi:10.1016/j.ajhg.2022.04.010. Epub 2022 May 16. PMID: 35580588 |
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Shahania, S., Unnikrishnan, V., Pryss, R., Kraft, R., Schobel, J., Hannemann, R., ... & Spiliopoulou, M. (2022). Predicting Ecological Momentary Assessments in an App for Tinnitus by Learning From Each User's Stream With a Contextual Multi-Armed Bandit. Frontiers in neuroscience, 16. |
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Jarach, C. M., Lugo, A., Stival, C., Bosetti, C., Amerio, A., Cavalieri d'Oro, L., Iacoviello L, Odone A, Stuckler D, Zucchi A, van den Brandt P, Garavello W, Cederroth CR, Schlee W, Gallus S and the LOST in Lombardia Study Investigators (2022). The impact of COVID-19 confinement on tinnitus and hearing loss in older adults: data from the LOST in Lombardia study. Frontiers in Neurology, 366. https://doi.org/10.3389/fneur.2022.838291 |
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Edvall NK, Mehraei G., Claeson M., Lazar A., Bulla J., Leineweber C., Uhlén I., Canlon B., Cederroth CR. (2022). Alterations in auditory brainstem response distinguish occasional and constant tinnitus. J Clin Invest. 2022 Jan 25:e155094. doi: 10.1172/JCI155094. Epub ahead of print. PMID: 35077399. |
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Prakash S, Unnikrishnan V, Pryss R, Kraft R, Schobel J, Hannemann R, Langguth B, Schlee W, Spiliopoulou M. (2021) Interactive System for Similarity-Based Inspection and Assessment of the Well-Being of mHealth Users. Entropy. 2021; 23(12):1695. https://doi.org/10.3390/e23121695 |
| only abstract available | Puga, C., Niemann, U., Unnikrishnan, V., Schleicher, M., Schlee, W., & Spiliopoulou, M. (2021, October). Discovery of Patient Phenotypes through Multi-layer Network Analysis on the Example of Tinnitus. In 2021 IEEE 8th International Conference on Data Science and Advanced Analytics (DSAA) (pp. 1-10). IEEE. |
| only abstract available | Genitsaridi E, Kypraios T, Edvall NK, Trpchevska N, Canlon B, Hoare DJ, Cederroth CR, Hall DA (2021). The spatial percept of tinnitus is associated with hearing asymmetry: Subgroup comparisons. Prog Brain Res. 2021;263:59-80. doi: 10.1016/bs.pbr.2021.04.00610.1016/bs.pbr.2021.04.006. Epub 2021 May 20. PMID: 4243891. |
| only abstract available | Biswas R, Lugo A, Genitsaridi E, Trpchevska N, Akeroyd MA, Cederroth CR, Liu X, Schlee W, Garavello W, Gallus S, Hall DA (2021). Modifiable lifestyle-related risk factors for tinnitus in the general population: An overview of smoking, alcohol, body mass index and caffeine intake. Prog Brain Res. 2021;263:1-24. doi:10.1016/bs.pbr.2021.04.005. Epub 2021 May 20. PMID: 34243884 |
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Schoisswohl, S., Langguth, B., Schecklmann, M., Boecking, B., Cederroth, C., Chalanouli, D., ... & Schlee, W. (2021). Unification of treatments and interventions for tinnitus patients (UNITI): a study protocol for a multi-center randomized clinical trial. Trials 22, 875 (2021). https://doi.org/10.1186/s13063-021-05835-z |
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Amanat, S., Gallego-Martinez, A., Sollini, J., Perez-Carpena, P., Espinosa-Sanchez, J. M., Aran, I., ... & Lopez-Escamez, J. A. (2021). Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine, 66, 103309. |
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Trochidis I, Lugo A, Borroni E, Cederroth CR, Cima R, Kikidis D, Langguth B, Schlee W, Gallus S. Systematic Review on Healthcare and Societal Costs of Tinnitus. International Journal of Environmental Research and Public Health. 2021; 18(13):6881. https://doi.org/10.3390/ijerph18136881. |
| only abstract available |
Schlee, W., Langguth, B., Pryss, R., Allgaier, J., Mulansky, L., Vogel, C., Spiliopoulou, M., Schleicher, M., Unnikrishnan, V., Puga, C., Manta, O., Sarafidis, M., Kouris, I., Vellidou, E., Koutsouris, D., Koloutsou, K., Spanoudakis, G., Cederroth, C., & Kikidis, D. (2021). Using Big Data to Develop a Clinical Decision Support System for Tinnitus Treatment. Current topics in behavioral neurosciences, 10.1007/7854_2021_229. Advance online publication. https://doi.org/10.1007/7854_2021_229. |
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Kikidis, D., Vassou, E., Markatos, N., Schlee, W., & Iliadou, E. (2021). Hearing Aid Fitting in Tinnitus: A Scoping Review of Methodological Aspects and Effect on Tinnitus Distress and Perception. Journal of Clinical Medicine, 10(13), 2896. https://doi.org/10.3390/jcm10132896 |
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Kikidis, D., Vassou, E., Schlee, W., Iliadou, E., Markatos, N., Triantafyllou, A., & Langguth, B. (2021). Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers. Journal of clinical medicine, 10(8), 1737. https://doi.org/10.3390/jcm10081737. |
| only abstract available |
Schlee W, Schoisswohl S, Staudinger S, Schiller A, Lehner A, Langguth B, Schecklmann M, Simoes J, Neff P, Marcrum SC, Spiliopoulou M, Niemann U, Schleicher M, Unnikrishnan V, Puga C, Mulansky L, Pryss R, Vogel C, Allgaier J, Giannopoulou E, Birki K, Liakou K, Cima R, Vlaeyen JWS, Verhaert N, Ranson S, Mazurek B, Brueggemann P, Boecking B, Amarjargal N, Specht S, Stege A, Hummel M, Rose M, Oppel K, Dettling-Papargyris J, Lopez-Escamez JA, Amanat S, Gallego-Martinez A, Escalera-Balsera A, Espinosa-Sanchez JM, Garcia-Valdecasas J, Mata-Ferron M, Martin-Lagos J, Martinez-Martinez M, Martinez-Martinez MJ, Müller-Locatelli N, Perez-Carpena P, Alcazar-Beltran J, Hidalgo-Lopez L, Vellidou E, Sarafidis M, Katrakazas P, Kostaridou V, Koutsouris D, Manta R, Paraskevopoulos E, Haritou M, Elgoyhen AB, Goedhart H, Koller M, Shekhawat GS, Crump H, Hannemann R, Holfelder M, Oberholzer T, Vontas A, Trochidis I, Moumtzi V, Cederroth CR, Koloutsou K, Spanoudakis G, Basdekis I, Gallus S, Lugo A, Stival C, Borroni E, Markatos N, Bibas A, Kikidis D. (2021). Towards a unification of treatments and interventions for tinnitus patients: The EU research and innovation action UNITI. Progress in brain research, 260, 441–451. https://doi.org/10.1016/bs.pbr.2020.12.005. |
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Schleicher, M., Unnikrishnan, V., Neff, P., Simoes, J., Probst, T., Pryss, R., Schlee, W. & Spiliopoulou, M. (2020). Understanding adherence to the recording of ecological momentary assessments in the example of tinnitus monitoring. Scientific Reports, 10, 22459 (2020). https://doi.org/10.1038/s41598-020-79527-0. |
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Unnikrishnan, V., Schleicher, M., Shah, Y., Jamaludeen, N., Pryss, R., Schobel, J., Kraft, R., Schlee, W., & Spiliopoulou, M. (2020). The Effect of Non-Personalised Tips on the Continued Use of Self-Monitoring mHealth Applications. Brain sciences, 10(12), 924. https://doi.org/10.3390/brainsci10120924. |
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Trpchevska, N., Bulla, J., Prada Hellberg, M., Edvall, N. K., Lazar, A., Mehraei, G., Uhlen, I., Schlee, W., Canlon, B., Gallus, S., Lopez-Escamez, J. A., & Cederroth, C. R. (2020). Sex-Dependent Aggregation of Tinnitus in Swedish Families. Journal of clinical medicine, 9(12), 3812. https://doi.org/10.3390/jcm9123812. |
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Schlee, W., Hølleland, S., Bulla, J., Simoes, J., Neff, P., Schoisswohl, S., Woelflick, S., Schecklmann, M., Schiller, A., Staudinger, S., Probst, T., & Langguth, B. (2020). The Effect of Environmental Stressors on Tinnitus: A Prospective Longitudinal Study on the Impact of the COVID-19 Pandemic. Journal of clinical medicine, 9(9), 2756. https://doi.org/10.3390/jcm9092756. |
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Cederroth, C. R., Lugo, A., Edvall, N. K., Lazar, A., Lopez-Escamez, J. A., Bulla, J., Uhlen, I., Hoare, D. J., Baguley, D. M., Canlon, B., & Gallus, S. (2020). Association between Hyperacusis and Tinnitus. Journal of clinical medicine, 9(8), 2412. https://doi.org/10.3390/jcm9082412. |
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Niemann, U., Brueggemann, P., Boecking, B., Mebus, W., Rose, M., Spiliopoulou, M., & Mazurek, B. (2020). Phenotyping chronic tinnitus patients using self-report questionnaire data: Cluster analysis and visual comparison. Scientific reports, 10(1), 1-10. ISO 690. https://doi.org/10.1038/s41598-020-73402-8. |
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Niemann, U., Boecking, B., Brueggemann, P., Mazurek, B., & Spiliopoulou, M. (2020). Gender-Specific Differences in Patients With Chronic Tinnitus-Baseline Characteristics and Treatment Effects. Frontiers in neuroscience, 14, 487. https://doi.org/10.3389/fnins.2020.00487. |
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Niemann U, Brueggemann P, Boecking B, Mazurek B, Spiliopoulou M. (2020) Development and internal validation of a depression severity prediction model for tinnitus patients based on questionnaire responses and socio-demographics. Scientific reports. 2020 Mar 13;10(1):1-9. https://doi.org/10.1038/s41598-020-61593-z. |
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Niemann U, Boecking B, Brueggemann P, Mebus W, Mazurek B, Spiliopoulou M. (2020) Tinnitus related distress after multimodal treatment can be characterized using a key subset of baseline variables. PLoS One. 2020 Jan 30;15(1):e0228037. PMID: 31999776; PMCID: PMC6991951. https://doi.org/10.1371/journal.pone.0228037. |
Conference technical papers
| Only abstract available | Schleicher, M., Unnikrishnan, V., Pryss, R., Schobel, J., Schlee, W., & Spiliopoulou, M. (2023). Prediction meets time series with gaps: User clusters with specific usage behavior patterns. Artificial Intelligence in Medicine, 142, 102575. https://doi.org/10.1016/j.artmed.2023.102575. |
| Only abstract available |
Unnikrishnan, V., Schleicher, M., Puga, C., Pryss, R., Vogel, C., Schlee, W., & Spiliopoulou, M. (2023, April). A Similarity-Guided Framework for Error-Driven Discovery of Patient Neighbourhoods in EMA Data. In Advances in Intelligent Data Analysis XXI: 21st International Symposium on Intelligent Data Analysis, IDA 2023, Louvain-la-Neuve, Belgium, April 12–14, 2023, Proceedings (pp. 459-471). Cham: Springer Nature Switzerland. https://doi.org/10.1007/978-3-031-30047-9_36. |
| Only abstract available | Manta, O., Sarafidis, M., Schlee, W., Consoulas, C., Kikidis, D., & Koutsouris, D. (2022, July). Electrophysiological differences in distinct hearing threshold level individuals with and without tinnitus distress. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 1630-1633). IEEE.https://doi.org/10.1109/embc48229.2022.9871392 |
| Only abstract available | Schleicher, M., Hamacher, S., Naujoks, M., Günther, K., Schmidt, T., Pryss, R., ... & Spiliopoulou, M. (2022, July). Prediction of declining engagement to self-monitoring apps on the example of tinnitus mHealth data. In 2022 IEEE 35th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 228-233). IEEE. https://doi.org/10.1109/CBMS55023.2022.00047 |
| Only abstract available | Schleicher, M., Pryss, R., Schobel, J., Schlee, W., & Spiliopoulou, M. (2022, October). Expect the gap: A recommender approach to estimate the absenteeism of self-monitoring mHealth app users. In 2022 IEEE 9th International Conference on Data Science and Advanced Analytics (DSAA) (pp. 1-10). IEEE. https://doi.org/10.1109%2fDSAA54385.2022.10032390 |
| Only abstract available | Bromis, K., Sarafidis, M., Manta, O., Kouris, I., Vellidou, E., Schlee, W., & Koutsouris, D. (2022, July). Predicting the optimal therapeutic intervention for tinnitus patients using random forest regression: A preliminary study of UNITI's decision support system model. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 2655-2658). IEEE. https://doi.org/10.1109/embc48229.2022.9871331 |
| Only abstract available | Schleicher, M., Pryss, R., Schlee, W., & Spiliopoulou, M. (2022, June). When can I expect the mHealth user to return? Prediction meets time series with gaps. In International Conference on Artificial Intelligence in Medicine (pp. 310-320). Cham: Springer International Publishing. https://doi.org/10.1016/j.artmed.2023.102575 |
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Shahania, S., Unnikrishnan, V., Pryss, R., Kraft, R., Schobel, J., Hannemann, R., Schlee, W., & Spiliopoulou, M. (2021, June). User-centric vs whole-stream learning for EMA prediction. In 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 307-312). IEEE. https://doi.org/10.1109/CBMS52027.2021.00033. |
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Unnikrishnan, V., Shah, Y., Schleicher, M., Fernández-Viadero, C., Strandzheva, M., Velikova, D., Schlee, W., & Spiliopoulou, M. (2021, June). Love thy Neighbours: A Framework for Error-Driven Discovery of Useful Neighbourhoods for One-Step Forecasts on EMA data. In 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 295-300). IEEE. https://doi.org/10.1109/CBMS52027.2021.00080. |
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Jamaludeen, N., Unnikrishnan, V., Pryss, R., Schobel, J., Schlee, W., & Spiliopoulou, M. (2021, June). Circadian Conditional Granger Causalities on Ecological Momentary Assessment Data from an mHealth App. In 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 354-359). IEEE. https://doi.org/10.1109/CBMS52027.2021.00110. |
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Sarafidis, M., Manta, O., Kouris, I.N., Schlee, W., Kikidis, D., Vellidou, E., & Koutsouris, D.D. (2021). Why a Clinical Decision Support System is needed for Tinnitus?. 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). |
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Allgaier, J., Neff, P., Schlee, W., Schoisswohl, S., & Pryss, R. (2021). Deep Learning End-to-End Approach for the Prediction of Tinnitus based on EEG Data. 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). |
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Vogel, C., Schobel, J., Schlee, W., Engelke, M., & Pryss, R. (2021). UNITI Mobile - EMI-Apps for a Large-Scale European Study on Tinnitus. ArXiv, abs/2107.14029. 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). |
