UNITI results 20231201

UNITI results

UNITI project finished in September 2023. It’s overall aim was to deliver a predictive computational model based on existing and longitudinal data attempting to address the question which treatment approach is optimal for a specific patient based on specific parameters. Clinical, epidemiological, medical, genetic and audiological data, including signals reflecting ear-brain communication, were analysed from existing databases. Predictive factors for different patient groups were extracted and their prognostic relevance were tested in a randomized controlled trial (RCT) in which different groups of patients underwent a combination of therapies targeting the auditory and central nervous systems.

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Defective α tectorin may involve tectorial membrane in familial Meniere diseaseWe are happy to announce that we have a new paper published in Clinical and Translational Medicine: "Defective α-tectorin may involve tectorial membrane in familial Meniere disease". Although there have been considerable advances in recent years, the contribution of genetic factors to Meniere's disease (MD) is not yet fully understood.The results of the present study add new evidence to support the involvement of α-tectorin in the pathophysiology of MD. We report four multicase MD families carrying rare missense heterozygous variants (F1–F3) and a short deletion (F4) in the coding region of the TECTA gene. Variants in this gene were also found in two additional families with one MD patient and relatives with partial syndromes carrying a missense heterozygous variant (F5) and a short deletion (F6). More information can be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162437/ 

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Key Facts

Data and analysis scripts of the UNITI-RCT results are currently available upon request (stefan.schoisswohl@klinik.uni-regensburg.de).

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