UNITI results 20231201

UNITI results

UNITI project finished in September 2023. It’s overall aim was to deliver a predictive computational model based on existing and longitudinal data attempting to address the question which treatment approach is optimal for a specific patient based on specific parameters. Clinical, epidemiological, medical, genetic and audiological data, including signals reflecting ear-brain communication, were analysed from existing databases. Predictive factors for different patient groups were extracted and their prognostic relevance were tested in a randomized controlled trial (RCT) in which different groups of patients underwent a combination of therapies targeting the auditory and central nervous systems.

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Alterations in auditory brainstem response distinguish occasional and constant tinnitusWe are happy to announce that we have a new paper published: "Alterations in auditory brainstem response distinguish occasional and constant tinnitus" and is available as open access here: https://www.jci.org/articles/view/155094/pdf.

The authors determined that with increasing frequency of the occasional perception of self- reported tinnitus, the odds of reporting constant tinnitus after 2 years increases from 5 for previous tinnitus (sometimes) to 30 for previous tinnitus (often). When previous tinnitus was reported to be constant, the odds of reporting it as constant after 2 years rose to 603, suggesting that once transitioned to constant tinnitus, the likelihood of tinnitus to persist was much greater. Auditory brainstem responses (ABRs) from subjects reporting non-tinnitus (controls), occasional tinnitus, and constant tinnitus show that wave V latency increased in constant tinnitus when compared to occasional tinnitus or non-tinnitus. The ABR from occasional tinnitus was indistinguishable from that of the non-tinnitus controls.


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Key Facts

Data and analysis scripts of the UNITI-RCT results are currently available upon request (stefan.schoisswohl@klinik.uni-regensburg.de).

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