A list of potential candidate genes related to tinnitus has been developed. These genes showing an overload of rare variants were selected and used in the algorithm for the DSS. Shared genes across different analyses provided insights into potential genetic factors contributing to tinnitus susceptibility and severity.
Protein biomarker analysis for tinnitus was conducted in two cohorts, using a retrospective case-control approach. Despite a methodologically robust analysis of 92 neurology proteins, no significant associations were found with tinnitus. The findings suggests that future research should focus utilize expanded proteomics platforms to increase the likelihood of identifying relevant molecular biomarkers. Moreover, the protein biomarker data of the RCT patients have been integrated into the DSS.
Relevant work:
- Gallego-Martinez A, Escalera-Balsera A, Trpchevska N et al. Using coding and non- coding rare variants to target candidate genes in patients with severe tinnitus. NPJ Genom Med. 2022 Nov 30;7(1):70. doi: 10.1038/s41525-022- 00341-wGallego-Martinez A, Escalera-Balsera A, Trpchevska N et al. Using coding and non- coding rare variants to target candidate genes in patients with severe tinnitus. NPJ Genom Med. 2022 Nov 30;7(1):70. doi: 10.1038/s41525-022- 00341-w.
- Amanat S, Gallego- Martinez A, Sollini J et al. Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine. 2021 Apr;66:103309. doi:10.1016/j.ebiom.2021 .103309.
